Quantifying IED impact on macroscale dynamics and microcircuit organization

Ascertain the extent to which interictal epileptiform discharges (IEDs) affect macroscale intrinsic brain dynamics and microcircuit organization, in order to substantiate their pathological relevance.

Background

Interictal epileptiform discharges (IEDs) are key EEG markers in epilepsy and are clinically important for diagnosis and treatment. Despite their importance, the degree to which IEDs alter large-scale intrinsic dynamics and local microcircuit organization is not established.

Clarifying these effects would validate the pathological relevance of IEDs and refine network-level models of seizure generation and propagation.

References

However, it is not clear to what extent the IEDs affect macroscale intrinsic dynamics and microcircuit organizations, that supports their pathological relevance.

— Differential Dynamic Causal Nets: Model Construction, Identification and Group Comparisons  (2601.21478 - You et al., 29 Jan 2026) in Results, subsection “Differential causal nets between cases and controls,” opening paragraph