Existence of nontrivial quantum field theories satisfying the Wightman axioms
Establish, for at least one four-dimensional quantum field theory used in particle physics (such as quantum electrodynamics or Yang–Mills theory), the existence of nontrivial solutions that satisfy the Wightman axioms by constructing the theory non-perturbatively and proving that it fulfills the full set of axioms (Lorentz invariance, locality, spectral condition, etc.).
References
Both are in excellent agreement with observations, but the problem is that we do not know whether any among the field theories we use in particle physics admits non-trivial solutions satisfying the Wightman axioms.
— From Many Models to ONE THEORY
(2501.10233 - Iliopoulos, 17 Jan 2025) in Section: Elementary Particles—The origins (discussion of Wightman axioms)