Diophantine definability of Z over Q
Determine whether the ring of integers Z is Diophantine over the field of rationals Q; that is, establish whether there exists a polynomial F(t,x1,…,xn) with integer coefficients such that for every t in Q, t is in Z if and only if there exist x1,…,xn in Q satisfying F(t,x1,…,xn)=0.
References
However, there are conjectures by Mazur and others implying that such a definition does not exist. The question concerning (non)existence of this Diophantine definition is another major problem in the area.
                — In Memory of Martin Davis
                
                (2401.10154 - Calvert et al., 15 Jan 2024) in Subsection “The question of Q” (Section: Hilbert’s Tenth Problem)