Determine all homotopy groups of spheres
Determine the homotopy groups π_k(S^n) of spheres S^n for all integers k ≥ n ≥ 2, providing a complete specification of π_k(S^n) across all dimensions.
References
The surprise comes with the result that \pi_k(Sn) is non-trivial for most (but certainly not all) k \geq n \geq 2, and in fact mathematicians have not yet determined all the homotopy groups of spheres for arbitrary k and n.
— Algebraic Topology
(1304.7846 - Robins, 2013) in Subsection "Extensions and applications" within Section "Homotopy Theory"