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Clarify CDK10’s role in adrenocortical cell proliferation

Determine whether Cyclin-dependent kinase 10 (CDK10) functions primarily as a promoter or a suppressor of adrenocortical cell proliferation and elucidate its role in G2/M phase regulation in the H295R-S2 a7-5HT3-R model and aldosterone-producing adenomas.

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Background

CDK10 was identified within the sodium-induced transcriptomic signature in this paper, with increased expression following uPSEM-817 treatment. Literature reports conflict on CDK10’s function, with studies supporting both pro-proliferative and tumor-suppressive roles.

Resolving CDK10’s role in adrenocortical cells is necessary to interpret its upregulation under sodium influx and to understand how it may influence proliferation and APA biology.

References

However, the role of CDK10 in regulating cell proliferation is not clear, as some studies suggest a role of CDK10 in cell proliferation activation45-47, while others report a tumor suppressor role for CDK10 through inhibition of cell proliferation48,49.

— Modulation of Calcium Signaling on Demand to Decipher the Molecular Mechanisms of Primary Aldosteronism (2507.15353 - Fedlaoui et al., 21 Jul 2025) in Discussion — Sodium-induced transcriptomic signature (mid Discussion)