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Complete replication cycle of CHIKV in mammalian cells

Elucidate the complete replication cycle of Chikungunya virus in mammalian cells, including the sequence of molecular events and roles of viral components required for successful replication.

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Background

While many aspects of CHIKV replication have been characterized, important details of how replication proceeds in mammalian cells remain incomplete. The paper highlights that recent studies have added insights into replicase function, but a full understanding is lacking.

References

In mammalian cells, the CHIKV replication cycle has not been fully understood.

Chikungunya: The Silent Threat in the Shadows (2411.12779 - Talib et al., 19 Nov 2024) in Section 5.3. Genome replication