Determine whether poorly exposed targets co-occur with unfavorable biological states

Determine whether low reaction burden and unfavorable biological state co-occur within the same BNCT target cells, thereby establishing whether such dependence contributes to the biological response.

Background

The paper’s marked-event framework models survival as depending on the joint target-level relationship between reaction intensity and event quality, rather than on their separate marginal distributions. It shows that identical marginal distributions can produce different survival outcomes when the pairing between reaction burden and biological context differs.

The authors identify the possible co-occurrence of poor exposure and unfavorable biological state as an empirically unresolved issue. The framework deliberately does not assign this dependence to any particular cell class, so determining whether it exists requires target-resolved biological and exposure measurements.

References

Whether such co-occurrence exists is an empirical question; the framework does not assign it to any specific cell class.

— A No-Go Framework for Coarse-Grained Effect Prediction in Boron Neutron Capture Therapy: Structural Identifiability Limits and Microscopic Coverage  (2610.07667 - Fujimura et al., 6 Oct 2026) in Section 3.1, Discussion