Emergent cell migration from cell shape deformations and T1 transitions

Abstract: T1 transitions, which are localised cell rearrangements, play an important role in the fluidization of epithelial monolayers. Using a multi-phase field model and an active elastic solid model, we show that although each cell undergoes T1 transitions in time as uncorrelated, random events, the spatial distribution of these events is highly correlated and is dependent on cell shape. T1 transitions have a dual effect. Cells losing neighbours tend to relax their shape, while those gaining neighbours tend to elongate. By analysing the statistics of successive T1 transitions undergone by a deformable cell, we find asymmetric spatial distributions related to how cells lose or gain neighbours. These asymmetric spatial patterns of T1 transitions promote directed cell migration, and form the backbone for coherent flow patterns at tissue scales.