Quantitative Photoacoustic Imaging of Two-photon Absorption

Abstract: Two-photon absorption photoacoustic tomography (TP-PAT) is a recent hybrid imaging modality that aims at reconstructing two-photon absorption properties of heterogeneous media from measured ultrasound signals generated by the photoacoustic effect. While there have been extensive experimental studies in recent years to show the great promises of TP-PAT, very little has been done on developing computational methods for quantitative image reconstruction in this imaging modality. In this work, we present a mathematical model for quantitative TP-PAT in diffusive media. We implemented a computational strategy for the reconstruction of the optical absorption coefficients, and provide numerical simulations based on synthetic acoustic data to demonstrate the feasibility of quantitative reconstructions in TP-PAT.