ARIES: A Scalable Multi-Agent Orchestration Framework for Real-Time Epidemiological Surveillance and Outbreak Monitoring

Abstract: Global health surveillance is currently facing a challenge of Knowledge Gaps. While general-purpose AI has proliferated, it remains fundamentally unsuited for the high-stakes epidemiological domain due to chronic hallucinations and an inability to navigate specialized data silos. This paper introduces ARIES (Agentic Retrieval Intelligence for Epidemiological Surveillance), a specialized, autonomous multi-agent framework designed to move beyond static, disease-specific dashboards toward a dynamic intelligence ecosystem. Built on a hierarchical command structure, ARIES utilizes GPTs to orchestrate a scalable swarm of sub-agents capable of autonomously querying World Health Organization (WHO), Center for Disease Control and Prevention (CDC), and peer-reviewed research papers. By automating the extraction and logical synthesis of surveillance data, ARIES provides a specialized reasoning that identifies emergent threats and signal divergence in near real-time. This modular architecture proves that a task-specific agentic swarm can outperform generic models, offering a robust, extensible for next-generation outbreak response and global health intelligence.