Deterministic Epidemic Models For Ebola Infection With Time-dependent Controls

Abstract: In this paper, we have studied epidemiological models for Ebola infection using nonlinear ordinary differential equations and optimal control theory. We considered optimal control analysis of SIR and SEIR models for the deadly Ebola infection using vaccination, treatment and educational campaign as time-dependent controls functions. We have applied indirect methods to study existing deterministic optimal control epidemic models for Ebola virus disease. These methods in optimal control are based on Hamiltonian function and the Pontryagin's maximum principle to construct adjoint equations and optimality systems. The forward-backward sweep numerical scheme with fourth-order Runge-Kutta method is used to solve the optimality system for the various control strategies. From our numerical illustrations, we can conclude that, effective educational campaigns and vaccination of susceptible individuals as were as effective treatments of infected individuals can help reduce the disease transmission.