Symmetry of forward and reverse path populations (1002.2402v2)

Abstract: In this note, we address formally the issue of symmetry for probabilities of different dynamical pathways in the forward and reverse directions of a conformational transition. Our discussion is based on a decomposition of equilibrium into opposing steady states, and makes clear the conditions necessary for symmetry to apply. From a practical point of view, we also discuss when approximate symmetry is to be expected.