Weak reversibility of the proposed ME model class

Determine whether a mathematical epidemiology model defined as the subclass of chemical reaction networks in Open Problem o:MEm can be weakly reversible, meaning each linkage class in the Feinberg–Horn–Jackson graph is strongly connected.

Background

Weak reversibility is a central structural property in CRN theory that often yields strong dynamical consequences (e.g., complex-balanced equilibria and stability).

The authors note ME and CRN models frequently lie on opposite sides of the weak-reversibility boundary, making it unclear if ME models adhering to their proposed CRN definition can satisfy weak reversibility.