Rectilinear crossing number of the complete graph
Determine, for each positive integer n, the minimum number of pairs of crossing straight-line segments in a drawing of the complete graph K_n formed by joining every pair of points in an n-point set in the plane.
References
As one example of an outstanding open question, we mention the rectilinear crossing number problem for the complete graph $K_n$: For a given set $S$ of $n$ points in the plane, draw all straight segments between pairs of points in~$S$, and count the pairs of segments that cross. What is the smallest number that can be obtained?
— NumPSLA -- An experimental research tool for pseudoline arrangements and order types
(2503.02336 - Rote, 4 Mar 2025) in Section 1, Introduction