Polynomial (monotone) Hirsch conjecture
Prove that the (monotone) graph diameter of every d-dimensional polytope with m facets is bounded above by a polynomial in d and m; equivalently, establish a polynomial upper bound on the length of the shortest (monotone) path between vertices along edges of the polytope.
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The existence of an efficient pivot rule for the simplex method is a notorious open question since the inception of the method by Dantzig in 1947, and could yield a strongly polynomial algorithm for linear optimization, as well as a proof of the polynomial (monotone) Hirsch conjecture. These are widely regarded as two of the most important open problems in the theory of linear programming.
In fact, it is not even known whether—independent of any pivot rule—a path of polynomial length between any two extreme points of a polyhedron is guaranteed to exist. This is currently referred to as the polynomial Hirsch conjecture, and it is a major open question in discrete mathematics.