Mutation invariance of the Alexander polynomial refinement
Determine whether the polynomial P_K is invariant under arbitrary link mutations, beyond the orientation-preserving mutations for which invariance is established.
References
An argument much like the proof of Lemma \ref{lem:flype_invar} can be used to show $P$ is invariant under orientation-preserving mutations, but we do not know if $P$ is mutation invariant in general. This is a natural question for further study.
— An Alexander Polynomial Refinement for Alternating Links, with Trapezoidal Properties
(2608.28484 - Boninger, 28 Aug 2026) in Remark following Theorem 5.3, Section 5, “Diagram Independence”