Mechanisms underlying the context-dependent versatility of Notch signaling

Characterize the mechanisms that confer context-dependent versatility to Notch signaling across diverse developmental and disease systems, including how ligand multiplicity and interaction modes generate varied responses.

Background

Notch signaling governs a wide array of developmental processes and disease states, coordinating oscillations, fate decisions, and pattern formation in different tissues. This work highlights how multiple ligands might be harnessed to produce versatile responses in one context (the segmentation clock).

Despite extensive paper, a general mechanistic understanding of how Notch achieves such diverse roles across biological contexts remains lacking, motivating broader investigation into ligand–receptor interactions, signaling modes, and network architectures that enable this versatility.