Kirby’s handle decomposition problem for 4-manifolds
Determine whether every closed simply connected 4-dimensional manifold admits a handle decomposition with no 3-handles.
References
For example, an open question proposed by Kirby is whether a closed simply connected $4$-manifold admits a handle decomposition with no $3$-handles.
— Passing through nondegenerate singularities in mean curvature flows
(2501.16678 - Sun et al., 28 Jan 2025) in Section 1.3 (Topological Implications)