Dice Question Streamline Icon: https://streamlinehq.com

General autocatalysis criterion for diffusion-driven instability in go-or-grow models

Formulate a general autocatalysis condition that guarantees diffusion-driven instability for the go-or-grow family of ODE–PDE systems with linear diffusion in the migrating population u and local kinetics for the proliferating population v, specifying how the partial derivative of the v-kinetic term with respect to v generalizes across transition-rate functions α(u,v), β(u,v), and growth g(u+v)v.

Information Square Streamline Icon: https://streamlinehq.com

Background

The paper reviews how diffusion-driven instabilities arise in ODE–PDE coupled systems and presents an autocatalysis condition in specific settings, leading to high-frequency instabilities and pattern formation.

The authors highlight the unresolved task of formulating a general autocatalysis criterion applicable across the go-or-grow model class, which would clarify instability mechanisms under broad switching and growth functions.

References

While we have reviewed a wide array of analytical and numerical results concerning this special class of mathematical models, several important mathematical questions remain unresolved. How can the autocatalysis condition autocatalysis be formulated for a general model within the go-or-grow family?

autocatalysis:

hv(uˉ,vˉ)>0.\frac{\partial h}{\partial v } (\bar u, \bar v) >0.

Go-or-Grow Models in Biology: a Monster on a Leash (2412.05191 - Thiessen et al., 6 Dec 2024) in Section 8 (Discussion), Open Problems