Synthesis and characterization of PEG-coated Zn$_{0.3}$Mn$_x$Fe$_{2.7-x}$O$_4$ nanoparticles as the dual T1/T2-weighted MRI contrast agent

Abstract: Super-paramagnetic nanoparticles (NPs) have been widely explored as magnetic resonance imaging (MRI) contrast agents because of a combination of favorable magnetic properties, biocompability and ease of fabrication. MRI using traditional T1- or T2-weighted single mode contrast-enhanced techniques may yield inaccurate imaging results. In the present work, a T1/T2 dual mode contrast agent based on the super-paramagnetic zinc-manganese ferrite (Zn${0.3}$Mn$_x$Fe${2.7-x}$O$4$, x= 0, 0.25, 0.75 and 1) NPs with small core size and a hydrophilic PEG surface coating is reported. The TEM, TGA and FTIR results confirmed the formation of a uniform coating on the NPs surface. The MRI analysis revealed that the Zn${0.3}$Mn${0.5}$Fe${2.2}$O$4$ NPs had the maximum image contrast compared to other zinc-manganese ferrite samples. Cell viability evaluations revealed that the coated and uncoated particles did not inhibit cell growth pattern. The present PEG-coated Zn${0.3}$Mn${0.5}$Fe${2.2}$O$_4$ NPs can be utilized as a suitable T1/T2-weighted MRI contrast agent for better diagnostic of abnormalities in the organs or tissues.