Parsimonious Computing: A Minority Training Regime for Effective Prediction in Large Microarray Expression Data Sets

Abstract: Rigorous mathematical investigation of learning rates used in back-propagation in shallow neural networks has become a necessity. This is because experimental evidence needs to be endorsed by a theoretical background. Such theory may be helpful in reducing the volume of experimental effort to accomplish desired results. We leveraged the functional property of Mean Square Error, which is Lipschitz continuous to compute learning rate in shallow neural networks. We claim that our approach reduces tuning efforts, especially when a significant corpus of data has to be handled. We achieve remarkable improvement in saving computational cost while surpassing prediction accuracy reported in literature. The learning rate, proposed here, is the inverse of the Lipschitz constant. The work results in a novel method for carrying out gene expression inference on large microarray data sets with a shallow architecture constrained by limited computing resources. A combination of random sub-sampling of the dataset, an adaptive Lipschitz constant inspired learning rate and a new activation function, A-ReLU helped accomplish the results reported in the paper.