Detection of magnetic nanoparticles (MNPs) using spin current nano-oscillator (SCNO) biosensor: A frequency-based rapid, ultra-sensitive, magnetic bioassay

Abstract: This Letter is a micromagnetic simulation-based study on the GHz-frequency ferromagnetic resonances for the detection of magnetic nanoparticles (MNPs) using spin current nano-oscillator (SCNO) operating in precession mode as a spintronic biosensor. The magnetic stray fields from the MNPs in an antibody-antigen-MNP complex on the SCNO surface modify the ferromagnetic resonance peaks and generate measurable resonance peak shifts. Moreover, our results strongly indicate the position-sensitive behavior of the SCNO biosensor and ways to eradicate this effect to facilitate better bio-sensing performance. Additionally, a study has been made on how nanoparticles with different sizes can alter the SCNO device performance. This simulation-based study on the SCNO device shows a promise of frequency-based nano-biosensor with a sensitivity of detecting even a single MNP, even in presence of thermal noise.