Papers
Topics
Authors
Recent
Detailed Answer
Quick Answer
Concise responses based on abstracts only
Detailed Answer
Well-researched responses based on abstracts and relevant paper content.
Custom Instructions Pro
Preferences or requirements that you'd like Emergent Mind to consider when generating responses
Gemini 2.5 Flash
Gemini 2.5 Flash 87 tok/s
Gemini 2.5 Pro 53 tok/s Pro
GPT-5 Medium 17 tok/s Pro
GPT-5 High 20 tok/s Pro
GPT-4o 106 tok/s Pro
Kimi K2 156 tok/s Pro
GPT OSS 120B 467 tok/s Pro
Claude Sonnet 4 37 tok/s Pro
2000 character limit reached

Probabilistic Principles for Biophysics and Neuroscience: Entropy Production, Bayesian Mechanics & the Free-Energy Principle (2410.11735v1)

Published 15 Oct 2024 in math-ph, math.MP, nlin.AO, physics.bio-ph, and q-bio.NC

Abstract: This thesis focuses on three fundamental aspects of biological systems; namely, entropy production, Bayesian mechanics, and the free-energy principle. The contributions are threefold: 1) We compute the entropy production for a greater class of systems than before, including almost any stationary diffusion process, such as degenerate diffusions where the driving noise does not act on all coordinates of the system. Importantly, this class of systems encompasses Markovian approximations of stochastic differential equations driven by colored noise, which is significant since biological systems at the macro- and meso-scale are generally subject to colored fluctuations. 2) We develop a Bayesian mechanics for biological and physical entities that interact with their environment in which we give sufficient and necessary conditions for the internal states of something to infer its external states, consistently with variational Bayesian inference in statistics and theoretical neuroscience. 3) We refine the constraints on Bayesian mechanics to obtain a description that is more specific to biological systems, called the free-energy principle. This says that active and internal states of biological systems unfold as minimising a quantity known as free energy. The mathematical foundation to the free-energy principle, presented here, unlocks a first principles approach to modeling and simulating behavior in neurobiology and artificial intelligence, by minimising free energy given a generative model of external and sensory states.

List To Do Tasks Checklist Streamline Icon: https://streamlinehq.com

Collections

Sign up for free to add this paper to one or more collections.

Summary

  • The paper presents the Free-Energy Principle as a conceptual framework grounded in dynamic principles for understanding self-organizing systems.
  • Within this framework, system boundaries enable internal states to encode beliefs via Bayesian inference, minimizing free energy as a proxy for surprise.
  • The FEP provides a unified account of adaptive behavior across diverse systems and implies potential developments in modeling theoretical and empirical systems.

Essay: The Free-Energy Principle Made Simpler but Not Too Simple

The essay on the free-energy principle (FEP), presented in the referenced paper, offers a comprehensive walkthrough of the foundational aspects of the principle while connecting these to the broader context of statistical physics and inference. It effectively reframes the FEP not as a specific hypothesis about empirical phenomena but as a conceptual framework grounded in dynamic principles that can be applied to a broad range of systems exhibiting self-organizing behavior.

Foundations of the Free-Energy Principle

The FEP hinges on the representation of a system's dynamics through stochastic differential equations. The contention is that, to be considered a coherent thing, a system must encode a boundary—conceptualized as a Markov blanket—that delineates it from its environment. The boundary mediates internal and external states, preserving the integrity of the system's internal states while interfacing with external fluctuations. This demarcation allows for identifying conditional dependencies that dictate how a system must behave to maintain coherence.

Bayesian Mechanics

Under the FEP's framework, these boundaries imply that internal states can encode beliefs about external states in a manner consistent with Bayesian inference. This framework aligns the structure of biological systems with the dynamics of Bayesian inferential processes. The authors argue that internal states are configured to minimize a quantity called free energy, which serves as a variational proxy for surprise or prediction error, guiding the system toward states that are less surprising given its model of the world.

Path of Least Action

A principal advantage of the FEP is that it allows systems to be described via a path of least action, akin to Hamilton's principle in classical mechanics. This path is determined by minimizing free energy, which can be thought of as aligning a system's beliefs with ambient environmental states. The authors highlight the teleological interpretation of this path: by minimizing free energy, a system self-organizes toward a configuration that effectively self-evidences its existence.

Contributions and Implications

The paper asserts the salience of the FEP in providing a unified account of adaptive behavior across a spectrum of systems, from the micro to the macroscopic. Practically, this entails simulating systems—biological or artificial—that demonstrate sentience in the sense of maintaining a bounded, coherent state against environmental perturbations. This simulation hinges on a viable generative model accurately reflecting the interactions between the system and its surroundings.

Moreover, the FEP provides a lens through which various phenomena—ranging from cell biology to human cognition—can be understood as manifestations of a fundamental drive for self-evidence. Its implications reach into disciplines requiring models of predictive processing and adaptive control, suggesting that sentient systems, from cells to intelligent agents, may utilize similar principles in self-maintenance and environmental interaction.

Speculative Future Directions

The authors imply potential developments in modeling both theoretical and empirical systems, urging further exploration in increasing the specificity of generative models. This infers that by enhancing the granularity with which systems are modeled, the beneficence of this principled framework will extend into more refined predictive technologies across scientific domains.

Conclusion

In summary, the presented explanation of the free-energy principle elucidates a compelling narrative from fundamental physical principles to a highly abstracted form of inference-based self-organization. The conceptual trajectory embodies a paradigm by which systems, perceived as coherent and sentient, can be understood through the computational lens of free energy minimization. The FEP, therefore, serves as a profound investigatory axis, reconciling the dynamics of diverse systems with foundational truths about their sustained existence.

Dice Question Streamline Icon: https://streamlinehq.com

Follow-Up Questions

We haven't generated follow-up questions for this paper yet.

Authors (1)