Papers
Topics
Authors
Recent
Detailed Answer
Quick Answer
Concise responses based on abstracts only
Detailed Answer
Well-researched responses based on abstracts and relevant paper content.
Custom Instructions Pro
Preferences or requirements that you'd like Emergent Mind to consider when generating responses
Gemini 2.5 Flash
Gemini 2.5 Flash 87 tok/s
Gemini 2.5 Pro 50 tok/s Pro
GPT-5 Medium 13 tok/s Pro
GPT-5 High 16 tok/s Pro
GPT-4o 98 tok/s Pro
GPT OSS 120B 472 tok/s Pro
Kimi K2 210 tok/s Pro
2000 character limit reached

Parameter Efficient Fine-Tuning of Segment Anything Model for Biomedical Imaging (2502.00418v2)

Published 1 Feb 2025 in cs.CV

Abstract: Segmentation is an important analysis task for biomedical images, enabling the study of individual organelles, cells or organs. Deep learning has massively improved segmentation methods, but challenges remain in generalization to new conditions, requiring costly data annotation. Vision foundation models, such as Segment Anything Model (SAM), address this issue through improved generalization. However, these models still require finetuning on annotated data, although with less annotations, to achieve optimal results for new conditions. As a downside, they require more computational resources. This makes parameter-efficient finetuning (PEFT) relevant. We contribute the first comprehensive study of PEFT for SAM applied to biomedical images. We find that the placement of PEFT layers is more important for efficiency than the type of layer for vision transformers and we provide a recipe for resource-efficient finetuning. Our code is publicly available at https://github.com/computational-cell-analytics/peft-sam.

List To Do Tasks Checklist Streamline Icon: https://streamlinehq.com

Collections

Sign up for free to add this paper to one or more collections.

Summary

  • The paper demonstrates that LoRA is the top-performing PEFT method for achieving high segmentation accuracy with fewer parameters.
  • The study systematically compares nine PEFT methods, revealing that selective approaches significantly reduce VRAM usage for large vision transformers.
  • The findings highlight that freezing the encoder and using QLoRA can effectively adapt SAM for biomedical tasks, paving the way for efficient image segmentation.

Parameter Efficient Fine-Tuning of Segment Anything Model

The paper by Teuber et al. presents a comprehensive paper on parameter-efficient fine-tuning (PEFT) of the Segment Anything Model (SAM) for biomedical image segmentation tasks. The primary objective is to leverage the broad segmentation capabilities of SAM while minimizing resource demands and annotation needs when adapting to new conditions and datasets in the biomedical field.

Context and Motivation

Biomedical image segmentation is a critical component in the analysis of medical and microscopy images. The task has traditionally relied on deep learning approaches, such as CellPose and Stardist, which often require significant adaptation and manual annotation when applied to new types of images or segmentation tasks. With the introduction of vision foundation models like SAM, which are trained on large datasets, there exists the potential to reduce the annotation burden significantly. However, the resource-intensive nature of fine-tuning these models remains a challenge, prompting the exploration of PEFT methods that maintain segmentation quality while reducing computational complexity.

Methodology

The paper systematically evaluates nine PEFT methods across multiple biomedical datasets, both in light microscopy and medical imaging contexts. The methods include selective approaches like Attention Tuning (Attn Tune) and Bias Tuning, as well as additive methods like LoRA and AdaptFormer. A notable contribution is the implementation of quantized LoRA (QLoRA) adapted for vision transformers (ViTs), aimed at further enhancing tuning efficiency.

The research distinguishes between two PEFT methods: selective finetuning, which updates a subset of parameters, and additive finetuning, which introduces additional parameters to optimize resource usage. The paper explores the architectural layout of SAM encompassing an image encoder, mask decoder, and prompt encoder, particularly focusing on fine-tuning strategies applied to the image encoder.

Key Findings

The experiments reveal that full fine-tuning typically yields the best segmentation quality; however, LoRA emerges as the top-performing PEFT method, offering a robust balance between parameter efficiency and segmentation accuracy. Although QLoRA demonstrates notable success for minor domain shifts, its effectiveness is limited when applied directly to SAM without prior domain-specific finetuning.

In terms of computational efficiency, results vary with the conduct of PEFT methods across different model sizes. While VRAM savings are marginal for smaller ViT architectures, significant memory usage reductions are observed for larger models when freezing the encoder.

Implications and Future Directions

This paper underscores the potential for PEFT methods to enable the broad applicability of foundation models like SAM in specialized domains such as biomedical imaging. By pioneering a resource-efficient finetuning workflow, the research facilitates practical segmentation tasks, drastically lowering the computational threshold required for model adaptation.

Practically, the paper suggests freezing the encoder in resource-constrained environments while recommending LoRA or QLoRA for medium resources conditions. Strategically, these models highlight opportunities for developers to implement PEFT methodologies, bridging the gap between high-capacity foundation models and task-specific efficiency needs.

The deployed approach signifies a substantial shift towards more accessible model adaptations for biomedical image segmentation. Emphasizing this, the authors intend ongoing contributions through future integration within frameworks that allow interactive data annotation and fine-tuning, encouraging further community-driven advancements in this field.

Conclusion

The examination into PEFT for SAM delineates new pathways for efficient domain adaptation in image segmentation tasks, particularly within the context of biomedical imaging. By exploring parameter-efficient strategies, this paper both lays the groundwork for theoretical explorations and provides tactical advancements for improving existing segmentation workflows. Future developments in this domain may well benefit from this foundational work to further enhance adaptability and efficiency in biomedical imaging disciplines.

Ai Generate Text Spark Streamline Icon: https://streamlinehq.com

Paper Prompts

Sign up for free to create and run prompts on this paper using GPT-5.

Dice Question Streamline Icon: https://streamlinehq.com

Follow-up Questions

We haven't generated follow-up questions for this paper yet.

Github Logo Streamline Icon: https://streamlinehq.com