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Prediction-Powered Inference (2301.09633v4)

Published 23 Jan 2023 in stat.ML, cs.AI, cs.LG, q-bio.QM, and stat.ME

Abstract: Prediction-powered inference is a framework for performing valid statistical inference when an experimental dataset is supplemented with predictions from a machine-learning system. The framework yields simple algorithms for computing provably valid confidence intervals for quantities such as means, quantiles, and linear and logistic regression coefficients, without making any assumptions on the machine-learning algorithm that supplies the predictions. Furthermore, more accurate predictions translate to smaller confidence intervals. Prediction-powered inference could enable researchers to draw valid and more data-efficient conclusions using machine learning. The benefits of prediction-powered inference are demonstrated with datasets from proteomics, astronomy, genomics, remote sensing, census analysis, and ecology.

Citations (55)

Summary

  • The paper introduces Prediction-Powered Inference, a statistical framework that enhances the reliability of inference by combining abundant machine learning predictions with limited, high-fidelity data.
  • A core component is the "rectifier," which measures prediction error using reliable data to adjust ML predictions and construct statistically valid confidence intervals and p-values.
  • This method yields narrower confidence intervals and improved statistical power compared to traditional methods, demonstrated across diverse applications like genomics and astronomy.

A Statistical Framework for Enhanced Inference with Machine Learning Predictions

The paper "Prediction-Powered Inference," authored by researchers from the University of California, Berkeley, introduces a novel methodology designed for improving statistical inference by integrating predictions from machine-learning (ML) systems with limited experimental data. This framework, termed 'prediction-powered inference,' seeks to achieve statistical validity by creating confidence intervals and p-values for statistical estimands, such as means and regression coefficients, accounting for both the abundance of ML predictions and the limited availability of high-fidelity data.

Statistical inference often contends with the trade-off between data abundance and reliability. Machine-learning systems can generate predictions en masse; however, these predictions are frequently marred by biases and errors. Traditional approaches, either relying entirely on high-quality but limited datasets or on ML predictions treated as reality, are limited in their applicability. The imputation method, which assumes predictions as accurate measures, risks significant statistical inaccuracies, while the classical method, using only reliable data, often lacks the power due to data scarcity.

The prediction-powered inference framework strategically marries the strengths of both these worlds: it uses the vast information embedded in ML predictions without compromising statistical guarantees, which is achieved by adjusting the inference results for prediction error using so-called 'rectifiers.'

Key Findings and Contributions

Rectifier and Confidence Construction:

The paper introduces the rectifier, a critical element designed to measure prediction error. Calculating the rectifier involves observing prediction bias using a small set of reliable data. From these calculations, they construct a confidence set which is then applied to rectify the predictions made by ML models, ensuring statistical validity. The confidence sets account for statistical fluctuations due to finite data samples, maintaining the robustness of inference results irrespective of the size of the gold-standard data.

Diverse Applications:

The authors demonstrate their approach using datasets from diverse domains including proteomics, astronomy, genomics, and more. They underline how, with appropriate rectification, ML predictions can yield narrower confidence intervals than their classical counterparts across a wide array of statistical problems.

Numerical and Empirical Advantages:

Empirical comparisons highlight quantitative advantages of prediction-powered inference. Specifically, when ML predictions are sufficiently accurate, the resulting confidence intervals are smaller, thereby enhancing the power and efficiency of statistical inferences. For example, in experiments estimating deforestation rates and galaxy classifications, more precise inference was feasible even with reduced reliance on exhaustive labeled datasets.

Assumptions and Theoretical Extensions

Theoretical Extensions to Convex Estimation:

The authors primarily focus on problems expressible as convex optimization tasks. They demonstrate that many real-world inference tasks such as regression fall into this framework. They offer extensive methodology to construct prediction-powered intervals for general statistical problems, extending even to settings where there is distribution shift, symmetrically leveraging ML input to aid inference in shifted data distributions.

Robust to Distributional Assumptions:

The framework is notably robust, not requiring the ML model predictions to adhere strictly to any specific assumptions, making it broadly applicable. The authors also extend the framework to account for both covariate and label shifts, enhancing its stability against changes in data-generating processes.

Future Directions

Implications for AI Development:

As AI systems become increasingly integral across scientific fields, ensuring their statistical contributions remain accurate is crucial. Prediction-powered inference provides a systematic way to integrate AI with traditional statistical inference, safeguarding against over-reliance on potentially biased predictions while tapping into AI's data processing capabilities.

Adaptive Enhancements:

Further research may focus on enhancing the framework’s applicability to non-convex problems or investigating adaptive techniques for dynamically estimating rectifiers in evolving ML models. Broader extensions could refine these techniques to aid in tasks such as hypothesis testing and effect size determination in high-dimensional spaces.

Challenges and Considerations:

Nevertheless, challenges remain in aligning theoretical constructs with practical constraints, notably in computational overhead and model training dynamics. Researchers must navigate these alongside the need to ensure transparency and explicability in ML predictions when used for consequential decisions or scientific insights.

In summary, this paper's contribution to prediction-powered inference is pivotal in reconciling contemporary data analytics with foundational statistical integrity, representing a significant step forward in the collaboration between ML systems and robust statistical inference methodologies.

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