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Deep Learning Applications for Lung Cancer Diagnosis: A systematic review (2201.00227v1)

Published 1 Jan 2022 in eess.IV, cs.CV, and cs.LG

Abstract: Lung cancer has been one of the most prevalent disease in recent years. According to the research of this field, more than 200,000 cases are identified each year in the US. Uncontrolled multiplication and growth of the lung cells result in malignant tumour formation. Recently, deep learning algorithms, especially Convolutional Neural Networks (CNN), have become a superior way to automatically diagnose disease. The purpose of this article is to review different models that lead to different accuracy and sensitivity in the diagnosis of early-stage lung cancer and to help physicians and researchers in this field. The main purpose of this work is to identify the challenges that exist in lung cancer based on deep learning. The survey is systematically written that combines regular mapping and literature review to review 32 conference and journal articles in the field from 2016 to 2021. After analysing and reviewing the articles, the questions raised in the articles are being answered. This research is superior to other review articles in this field due to the complete review of relevant articles and systematic write up.

Citations (29)

Summary

  • The paper conducts a systematic review of 32 studies to evaluate deep learning's role in automating lung cancer diagnosis.
  • It highlights that CNN-based models, including advanced variants like MTMR-Net and Mask R-CNN, achieve high accuracy, with some reaching up to 98.5%.
  • Researchers are urged to enhance model interpretability and dataset diversity to overcome challenges in imaging heterogeneity and annotation.

Deep Learning Applications for Lung Cancer Diagnosis: A Systematic Review

The paper "Deep Learning Applications for Lung Cancer Diagnosis: A Systematic Review" provides an extensive analysis of deep learning techniques applied to the automated detection and diagnosis of lung cancer. The research collates information from 32 prominent articles published between 2016 and 2021, providing detailed insights into the methodologies, datasets, and results utilized across the studies.

Overview

The paper emphasizes the prominence of lung cancer as a leading cause of mortality, highlighting the necessity for early and accurate detection methods. The paper notes that traditional techniques such as CT and MRI, while effective, require enhancement through automation and advanced image analysis. Deep learning, particularly Convolutional Neural Networks (CNNs), presents a significant advancement in this domain, facilitating efficient and precise diagnostics.

Methodology

The authors employ a dual approach using Systematic Mapping Study (SMS) and Systematic Literature Review (SLR) techniques to evaluate the existing literature. This comprehensive approach allows the analysis of various dimensions such as architecture, processing methods, and the integration of deep learning techniques into existing medical imaging frameworks.

Key Findings

  1. Algorithms and Architectures: Among the deep learning algorithms, CNNs are prominently used, with some studies proposing enhanced models like the Multi-Task Margin Ranking Loss Network (MTMR-Net) and innovative architectures such as the Mask Region-Convolutional Neural Network (Mask R-CNN). These architectures have shown varied levels of accuracy and sensitivity across different datasets.
  2. Performance Metrics: The studies reviewed reveal significant variations in accuracy and sensitivity. For instance, the AHHMM model reported a recognition rate of 96.67%, while a 3D Deep Convolutional Neural Network (3DDCNN) achieved an accuracy of 98.5%.
  3. Datasets: The LIDC-IDRI and LUNA-16 datasets are predominantly utilized across the reviewed studies, serving as benchmarks for training and evaluating deep learning models.
  4. Tools and Simulations: Python, with its libraries such as PyTorch and TensorFlow, is extensively used for model implementation, underscoring its centrality in deep learning research.
  5. Challenges and Limitations: The paper identifies challenges such as the heterogeneity of imaging data and the difficulty in accurately annotating datasets. These challenges necessitate continuous improvements in algorithmic robustness and computational efficiency.

Implications and Future Directions

The findings of the paper suggest that while there has been substantial progress in the application of deep learning for lung cancer diagnosis, there are significant opportunities for further research. The enhancement of model interpretability, the development of more comprehensive datasets, and the integration of multimodal data could potentially lead to more accurate and actionable diagnostic tools.

The implications for clinical practice are particularly promising—automating laborious and error-prone aspects of medical image analysis could enhance diagnostic precision and reduce the burden on medical professionals. Future research directions may involve exploring hybrid models that combine deep learning with other advanced techniques, such as reinforcement learning or generative models, to further improve diagnostic outcomes.

In conclusion, this systematic review underscores the transformative impact of deep learning on lung cancer diagnostics. By meticulously analyzing various studies, the paper not only maps the current landscape but also provides a foundation for subsequent research endeavors aimed at refining these promising technologies.