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Assessing the neurocognitive correlates of resting brain entropy (2004.13256v1)

Published 28 Apr 2020 in q-bio.NC

Abstract: The human brain exhibits large-scale spontaneous fluctuations that account for most of its total energy metabolism. Independent of any overt function, this immense ongoing activity likely creates or maintains a potential functional brain reserve to facilitate normal brain function. An important property of spontaneous brain activity is the long-range temporal coherence, which can be characterized by resting state fMRI-based brain entropy mapping (BEN), a relatively new method that has gained increasing research interest. The purpose of this study was to leverage the large resting state fMRI and behavioral data publicly available from the human connectome project to address three important but still unknown questions: temporal stability of rsfMRI-derived BEN; the relationship of resting BEN to latent functional reserve; associations of resting BEN to neurocognition. Our results showed that rsfMRI-derived BEN was highly stable across time; resting BEN in the default mode network (DMN) and executive control network (ECN) was related to brain reserve in a negative correlation to education years; and lower DMN/ECN BEN corresponds to higher fluid intelligence and better task performance. These results suggest that resting BEN is a temporally stable brain trait; BEN in DMN/ECN may provide a means to measure the latent functional reserve that bestows better brain functionality and may be enhanced by education.

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