Estimation of Causal Effects of Multiple Treatments in Observational Studies with a Binary Outcome

Abstract: There is a dearth of robust methods to estimate the causal effects of multiple treatments when the outcome is binary. This paper uses two unique sets of simulations to propose and evaluate the use of Bayesian Additive Regression Trees (BART) in such settings. First, we compare BART to several approaches that have been proposed for continuous outcomes, including inverse probability of treatment weighting (IPTW), targeted maximum likelihood estimator (TMLE), vector matching and regression adjustment. Results suggest that under conditions of non-linearity and non-additivity of both the treatment assignment and outcome generating mechanisms, BART, TMLE and IPTW using generalized boosted models (GBM) provide better bias reduction and smaller root mean squared error. BART and TMLE provide more consistent 95 per cent CI coverage and better large-sample convergence property. Second, we supply BART with a strategy to identify a common support region for retaining inferential units and for avoiding extrapolating over areas of the covariate space where common support does not exist. BART retains more inferential units than the generalized propensity score based strategy, and shows lower bias, compared to TMLE or GBM, in a variety of scenarios differing by the degree of covariate overlap. A case study examining the effects of three surgical approaches for non-small cell lung cancer demonstrates the methods.