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Generative AI in clinical practice: novel qualitative evidence of risk and responsible use of Google's NotebookLM (2505.01955v1)

Published 4 May 2025 in cs.AI

Abstract: The advent of generative artificial intelligence, especially LLMs, presents opportunities for innovation in research, clinical practice, and education. Recently, Dihan et al. lauded LLM tool NotebookLM's potential, including for generating AI-voiced podcasts to educate patients about treatment and rehabilitation, and for quickly synthesizing medical literature for professionals. We argue that NotebookLM presently poses clinical and technological risks that should be tested and considered prior to its implementation in clinical practice.

Analysis of Generative AI in Clinical Practice: Risks and Responsible Use of Google's NotebookLM

The paper "Generative AI in clinical practice: novel qualitative evidence of risk and responsible use of Google's NotebookLM" provides a critical examination of the application of generative AI, particularly the NotebookLM tool, in clinical settings. It confronts the current utility and limitations of AI-driven solutions in medical practice. This analysis is particularly relevant given the increasing integration of AI technologies in healthcare.

Presented by Dihan et al., the paper challenges the use of Google’s NotebookLM, which is intended to synthesize information from uploaded documents to provide summarized insights and generate educational content, such as AI-hosted podcasts. Although NotebookLM holds promise for enhancing educational and clinical resources, the paper highlights significant deficiencies and risks associated with its deployment.

Key findings illustrate NotebookLM's potential shortcomings, particularly in fact-checking and ensuring output accuracy. For instance, specific tests revealed instances where NotebookLM suggested inaccurate health advice, such as claiming "eating rocks is healthy" or miscalculating simple arithmetic operations (asserting $2 + 2 = 5$). These highlighted inaccuracies emphasize the need for caution in directly applying AI-generated content in medical advice without rigorous validation.

The paper details several clinical, ethical, and reliability concerns evidenced by NotebookLM's functionalities:

  • Patient Data Protection: The AI's capability to engage with electronic health records poses risks. Even though NotebookLM can theoretically facilitate rapid information synthesis, the paper warns about data privacy concerns, as user documents are susceptible to review or repurposing by third parties, raising HIPAA compliance issues.
  • Content Summarization: While AI-driven summaries offer efficiency, the risk of disseminating outdated or incorrect information remains prevalent, especially when documents contain conflicting viewpoints or data.
  • Educational Content: The use of AI-generated podcasts is critiqued for potential oversimplification and risk of multitasking-induced cognitive impairments. Such outputs may impact effective learning and accurate patient education.
  • Factual Accuracy and Citations: The paper critiques NotebookLM's fact-checking reliability and susceptibility to "hallucinations," where AI systems generate false information. This includes the generation of misleading citations, complicating the verification processes.

The claims are supported by illustrative examples, charts, and a structured evaluation of NotebookLM’s features against clinical criteria. Researchers cite not only internal assessments but align findings with documented risks in existing scholarly literature.

Implications of this research are profound. It calls for a guarded approach to integrating generative AI in clinical practice. The potential misinformation propagated by AI, privacy concerns, and accuracy issues demand thorough vetting and development of robust AI auditing mechanisms. It underscores the importance of collaborative, interdisciplinary oversight in AI tool deployment, especially in sensitive domains like healthcare.

In terms of future developments, this paper advocates for the advancement of AI systems focused on enhancing reliability, factual grounding, and patient-data protection. Such improvements could enable responsible AI integration, potentially revolutionizing medical records management and educational content generation, while adhering to ethical and privacy frameworks.

In summary, the paper emphasizes prudence concerning the deployment of generative AI in clinical environments. Understanding its limitations and responsibly navigating its implementation will be pivotal for progress in AI applications in healthcare.

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Authors (4)
  1. Max Reuter (6 papers)
  2. Maura Philippone (1 paper)
  3. Bond Benton (1 paper)
  4. Laura Dilley (1 paper)
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