Papers
Topics
Authors
Recent
Gemini 2.5 Flash
Gemini 2.5 Flash
144 tokens/sec
GPT-4o
8 tokens/sec
Gemini 2.5 Pro Pro
46 tokens/sec
o3 Pro
4 tokens/sec
GPT-4.1 Pro
38 tokens/sec
DeepSeek R1 via Azure Pro
28 tokens/sec
2000 character limit reached

Confinement-induced fractionation and liquid-liquid phase separation of polymer mixtures (2211.12896v1)

Published 23 Nov 2022 in cond-mat.soft

Abstract: The formation of (bio)molecular condensates via liquid-liquid phase separation in cells has received increasing attention, as these coacervates play important functional and regulatory roles within biological systems. However, the majority of studies focused on the behavior of pure systems in bulk solutions, thus neglecting confinement effects and the interplay between the numerous molecules present in cells. To advance our knowledge, we perform simulations of binary polymer mixtures in droplets, considering both monodisperse and polydisperse molecular weight distributions for the longer polymer species. We find that confinement induces a spatial separation of the polymers by length, with the shorter ones moving to the droplet surface. This partitioning causes a distinct increase of the local polymer concentration in the droplet center, which is more pronounced in polydisperse systems. Consequently, the systems exhibit liquid-liquid phase separation at average polymer concentrations where bulk systems are still in the one-phase regime.

Citations (1)

Summary

We haven't generated a summary for this paper yet.