Energy landscape analysis of cardiac fibrillation wave dynamics using pairwise maximum entropy model

Abstract: Cardiac fibrillation is characterized by chaotic and disintegrated spiral wave dynamics patterns, whereas sinus rhythm shows synchronized excitation patterns. To determine functional correlations among cardiomyocytes during complex fibrillation states, we applied a pairwise maximum entropy model (MEM) to the 2D numerical simulation data of human atrial fibrillation. We then constructed an energy landscape and estimated a hierarchical structure among the different local minima (attractors) to explain the dynamic properties of cardiac fibrillation. The MEM could describe the wave dynamics of sinus rhythm, single stable rotor, and single rotor with wavebreak (both accuracy and reliability>0.9), but not the multiple random wavelet case. The energy landscapes exhibited unique profiles of local minima and energy barriers, characterizing the spatiotemporal patterns of cardiac fibrillation dynamics. The pairwise MEM-based energy landscape analysis provides reliable explanations of complex nonlinear dynamics of cardiac fibrillation, which might be determined by the presence of a 'driver' such as a sinus node or rotor.