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Nonparametric methods for doubly robust estimation of continuous treatment effects (1507.00747v3)

Published 2 Jul 2015 in stat.ME

Abstract: Continuous treatments (e.g., doses) arise often in practice, but many available causal effect estimators are limited by either requiring parametric models for the effect curve, or by not allowing doubly robust covariate adjustment. We develop a novel kernel smoothing approach that requires only mild smoothness assumptions on the effect curve, and still allows for misspecification of either the treatment density or outcome regression. We derive asymptotic properties and give a procedure for data-driven bandwidth selection. The methods are illustrated via simulation and in a study of the effect of nurse staffing on hospital readmissions penalties.

Citations (257)

Summary

  • The paper proposes a novel nonparametric kernel smoothing method for doubly robust estimation of continuous treatment effects, ensuring consistency even if either the treatment density or outcome model is misspecified.
  • It introduces an efficient influence function and doubly robust mapping, providing consistent estimation and detailing the asymptotic properties under minimal assumptions.
  • Simulations show the method's favorable finite-sample robustness, and a real-world application reveals actionable insights, such as optimal ranges for nurse staffing effects on readmissions.

An Overview of Nonparametric Doubly Robust Estimation of Continuous Treatment Effects

The paper by Kennedy et al. introduces a novel nonparametric approach for estimating continuous treatment effects in causal inference, particularly emphasizing doubly robust estimation. Traditional causal effect estimators often rely on parametric models for the effect curve, limiting flexibility and robustness in practical applications. The authors propose a kernel smoothing technique that accommodates misspecification of either the treatment density or the outcome regression model, a feature that affirms the doubly robust nature of their methodology.

Key Contributions and Theoretical Underpinnings

The paper addresses two primary methodological challenges: the need for flexible estimation of dose-response curves and adequate adjustment for high-dimensional confounders. These challenges are prevalent in observational studies where treatments are continuous rather than binary. The authors extend semiparametric doubly robust methods by leveraging a kernel smoothing approach, which relies solely on mild smoothness assumptions for the effect curve, thereby avoiding the pitfalls of parametric assumptions.

Central to the paper is the derivation of a novel efficient influence function for a stochastic intervention parameter, which forms the basis of the proposed estimator. The authors utilize this influence function to develop a doubly robust mapping that allows for consistent estimation as long as either the treatment or the outcome model is correctly specified. The paper details the asymptotic properties of the estimator, providing conditions for consistency and asymptotic normality under minimal assumptions. The proposed method thus presents an advance in causal inference methodologies, offering a tool that combines nonparametric modeling with the benefits of doubly robust estimation.

Practical Implications and Numerical Results

The method's practical utility is underscored by simulations and an application examining the effect of nurse staffing on hospital readmission penalties. Simulations reveal favorable finite-sample properties of the estimator, demonstrating its robustness even when models are misspecified. The application to real-world hospital data highlights the estimator's capacity to uncover complex relationships between treatment and outcomes, suggesting actionable insights such as the benefits of certain ranges of nurse staffing hours.

Future Developments and Theoretical Implications

The approach proposed by Kennedy et al. underscores the potential of combining machine learning methods with causal inference tools to address high-dimensional and nonparametric settings. This integration paves the way for more effective handling of modern data complexities without resorting to restrictive parametric assumptions. Looking forward, further exploration could involve examining the uniform consistency and weak convergence properties of the estimator, essential for constructing tests with enhanced power.

In conclusion, the paper by Kennedy et al. offers a significant methodological contribution to the field of causal inference, presenting a doubly robust nonparametric approach capable of handling continuous treatments with improved flexibility and reliability. Such advancements are crucial for progressing towards more versatile causal estimation methods applicable in diverse real-world scenarios.

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