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Helix untwisting and bubble formation in circular DNA (1305.4051v1)

Published 17 May 2013 in q-bio.BM, cond-mat.soft, physics.bio-ph, and physics.chem-ph

Abstract: The base pair fluctuations and helix untwisting are examined for a circular molecule. A realistic mesoscopic model including twisting degrees of freedom and bending of the molecular axis is proposed. The computational method, based on path integral techniques, simulates a distribution of topoisomers with various twist numbers and finds the energetically most favorable molecular conformation as a function of temperature. The method can predict helical repeat, openings loci and bubble sizes for specific sequences in a broad temperature range. Some results are presented for a short DNA circle recently identified in mammalian cells.

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